In a study published in the Journal of the American Medical Association (JAMA), researchers found that regular use of low-dose aspirin to prevent cardiovascular events among high-risk patients may result in an increased risk of major bleeding. This study examined administrative records of 4.1 million individuals and using a matched case-control analysis, showed that aspirin use led to a greater risk of major gastrointestinal or cerebral bleeding. Individuals with diabetes had higher risk of bleeding, independent of aspirin use
De Berardis G, Lucisano G, D’Ettorre A, Pellegrini F, Lepore V, Tognoni G, Nicolucci A. Association of aspirin use with major bleeding in patients with and without diabetes. JAMA 2012;307: 2286-94.