There was no difference in mortality, the number of ischemic events, severe adverse reactions, or the numbers of days in the hospital between patients in the lower hemoglobin transfusion threshold group (7 g/dL) compared to those in the higher transfusion threshold group (9 g/dL). The lower-threshold group received a median of 1 unit of blood, while the higher-threshold group received a median of 4 units. By 90 days after randomization, 43% (216/502) of patients in the lower-threshold group had died compared to 45% (223/496) of the higher threshold group (relative risk, 0.94; 95% confidence interval, 0.78-1.09). Lower transfusion thresholds for septic shock patients use fewer units of RBCs and do not affect patient mortality.
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