VIDEO: Precision Medicine for the Transfusion Community


Today we will be discussing how “precision medicine” will affect the transfusion community.  Precision medicine, or “personalized medicine,” tailors treatments for patients based on their individual genomic differences and non-invasive monitoring. Dr. Harvey Klein explains how precision medicine is not new to the transfusion community: “Transfusion medicine was the first precision medicine when we matched […]

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VIDEO: RHD genotyping for obstetric patients with a serologic weak D phenotype


Today we will be discussing patients that have a weak D phenotype for their Rh blood group antigen. Since the introduction of Rh immunoprophylaxis to prevent maternal-fetal alloimmunization, rates of severe and fatal hemolytic disease of the fetus and newborn have dramatically declined. Although laboratory practices in the United States are not consistent, blood donors […]

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VIDEO: Dabigatran Anticoagulation Reversal

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Today we will be discussing a new drug called idarucizumab, which was developed to reverse the anticoagulant effects of dabigatran. Dr. Charles who is leading a multi-center, prospective study of idarucizumab describes dabigatran: “Dabigatran is a direct oral anticoagulant that works by inhibiting the function of factor IIa, thrombin, and it’s been licensed for the […]

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VIDEO: Platelet Rich Plasma Standards Are Needed


Today we will be discussing platelet rich plasma or PRP. Autologous PRP injections are quite common and are used to aid in wound healing. Autologous PRP injections have become quite common in many clinical settings ranging from the orthopedic setting to dermatology, especially since major athletes such as Tiger Woods, Kobe Bryant and Hines Ward […]

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VIDEO: Transfusion-Transmitted Dengue Infections in Brazil

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Hello and welcome to Transfusion News. Today we will be discussing transfusion-transmitted dengue virus infections that occurred during the 2012 outbreak in Brazil. Dengue is now present in over 100 counties. Since 2002, there have been documented transfusion-transmitted infections in Hong Kong, Singapore, Puerto Rico, and Brazil. Dr. Brian Custer describes his study on transfusion-transmitted […]

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VIDEO: Implementation of Pathogen Reduction in the United States


Today we will be discussing pathogen reduction which inactivates bacteria, viruses and parasites that may contaminate blood products. European countries have been using pathogen reduction systems for over 10 years, and the FDA has recently approved pathogen reduction systems for platelets and plasma. Pathogen reduction technology for red cells is lagging, but is under development. […]

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VIDEO: Innovative Ways to Think About TRALI May Reduce Cases

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Today we’ll be discussing TRALI, or transfusion-related acute lung injury. A major cause of TRALI is donor antibodies to white blood cells such as HLA and HNA, which activate leukocytes and neutrophils, and trigger the innate immune response. This process leads to acute lung injury. Other non-immune mediators, however, such as cell debris and biologically […]

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VIDEO: Fresher Red Blood Cells are Not Clinically Superior


Today we’ll be discussing transfusion of fresher versus older red blood cells. Over time, red cells develop altered structural and biochemical storage lesions. A variety of additive solutions, anticoagulation solutions, storage bags, and processing procedures affect red cell storage. FDA guidelines permit red cells to be stored for 42 days, but most units are transfused […]

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VIDEO: Newly Formed US Hemovigilance System for Transfusions Reports Similar Adverse Reaction Rates to Other Countries

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Today we will be discussing a newly formed United States hemovigilance system that tracks adverse reactions related to transfusions. While transfusions are the most common medical procedure performed in the United States, adverse reactions ranging from mild allergic reactions to severe life-threatening events can occur. Dr. Roger Dodd who wrote an editorial on the subject […]

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