VIDEO: Risk Factors for Fetal and Neonatal Alloimmune Thrombocytopenia


Today we will be discussing fetal and neonatal alloimmune thrombocytopenia, also referred to as NAIT, which affects about 1 in 1,000 births. NAIT is caused by maternal alloantibodies to specific platelet antigens, usually human platelet antigen 1a also referred to as HPA-1a. These antigens may be inherited from the father but are absent in the […]

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VIDEO: Cardiac Surgery in Patients who Refuse Transfusion is Not More Costly


Today we will be discussing cardiac surgery patients who refuse transfusions, such as Jehovah’s Witnesses.  Although the transfusion rate varies between 25% to 100% among cardiac surgery patients, cardiac surgeries without transfusions have been feasible for decades. Studies have even demonstrated improved outcomes in surgeries without transfusions. Dr. Guinn describes the standard treatment course for […]

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VIDEO: Daily Iron Supplements Decrease Iron Absorption


Today we will be discussing the best way to treat iron deficiency anemia which affects at least one billion people worldwide. Based on the Donor Iron Status Evaluation study which evaluated over 2,400 donors, iron deficiency anemia is problematic in frequent blood donors and affects at least two thirds of the women and half of […]

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VIDEO: Blood Donor Lead Levels and Concern for Infants and Children


Today we will be discussing lead levels in blood donors. Babies and young children are particularly susceptible to the neurotoxic effects of lead exposure.  Chronic developmental exposure to high lead levels can lead to lower IQ, behavioral problems, and developmental delays. While deteriorating lead paint is the primary exposure for children, another concerning route is […]

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VIDEO: Minimal Projected Loss of Blood Donors with Travel Deferral


Today we will be discussing projected blood donor loss if travel deferrals are implemented. Almost 20% of U.S. residents travel abroad each year. Acute viral infections like Chikungunya and dengue are common in much of the world. Dr. Louis Katz explains how a 14- or 28-day donor deferral period may help reduce transfusion transmitted infections: […]

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VIDEO: Viability of Hematopoietic Stem Cell Grafts Affects Clinical Outcomes


Today we will be discussing allogeneic hematopoietic stem cell (or HSC) grafts, which are often used to treat patients with malignant and benign hematologic disorders. Grafts are often collected from unrelated HLA matched donors since related donors are rarely available.  Transportation time and storage conditions are known to affect graft outcomes, but a recent article […]

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VIDEO: Precision Medicine for the Transfusion Community


Today we will be discussing how “precision medicine” will affect the transfusion community.  Precision medicine, or “personalized medicine,” tailors treatments for patients based on their individual genomic differences and non-invasive monitoring. Dr. Harvey Klein explains how precision medicine is not new to the transfusion community: “Transfusion medicine was the first precision medicine when we matched […]

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VIDEO: RHD genotyping for obstetric patients with a serologic weak D phenotype


Today we will be discussing patients that have a weak D phenotype for their Rh blood group antigen. Since the introduction of Rh immunoprophylaxis to prevent maternal-fetal alloimmunization, rates of severe and fatal hemolytic disease of the fetus and newborn have dramatically declined. Although laboratory practices in the United States are not consistent, blood donors […]

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VIDEO: Dabigatran Anticoagulation Reversal

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Today we will be discussing a new drug called idarucizumab, which was developed to reverse the anticoagulant effects of dabigatran. Dr. Charles who is leading a multi-center, prospective study of idarucizumab describes dabigatran: “Dabigatran is a direct oral anticoagulant that works by inhibiting the function of factor IIa, thrombin, and it’s been licensed for the […]

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VIDEO: Platelet Rich Plasma Standards Are Needed


Today we will be discussing platelet rich plasma or PRP. Autologous PRP injections are quite common and are used to aid in wound healing. Autologous PRP injections have become quite common in many clinical settings ranging from the orthopedic setting to dermatology, especially since major athletes such as Tiger Woods, Kobe Bryant and Hines Ward […]

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