VIDEO: Blood Donor Lead Levels and Concern for Infants and Children


Today we will be discussing lead levels in blood donors. Babies and young children are particularly susceptible to the neurotoxic effects of lead exposure.  Chronic developmental exposure to high lead levels can lead to lower IQ, behavioral problems, and developmental delays. While deteriorating lead paint is the primary exposure for children, another concerning route is […]

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VIDEO: Minimal Projected Loss of Blood Donors with Travel Deferral


Today we will be discussing projected blood donor loss if travel deferrals are implemented. Almost 20% of U.S. residents travel abroad each year. Acute viral infections like Chikungunya and dengue are common in much of the world. Dr. Louis Katz explains how a 14- or 28-day donor deferral period may help reduce transfusion transmitted infections: […]

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VIDEO: Viability of Hematopoietic Stem Cell Grafts Affects Clinical Outcomes


Today we will be discussing allogeneic hematopoietic stem cell (or HSC) grafts, which are often used to treat patients with malignant and benign hematologic disorders. Grafts are often collected from unrelated HLA matched donors since related donors are rarely available.  Transportation time and storage conditions are known to affect graft outcomes, but a recent article […]

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VIDEO: Precision Medicine for the Transfusion Community


Today we will be discussing how “precision medicine” will affect the transfusion community.  Precision medicine, or “personalized medicine,” tailors treatments for patients based on their individual genomic differences and non-invasive monitoring. Dr. Harvey Klein explains how precision medicine is not new to the transfusion community: “Transfusion medicine was the first precision medicine when we matched […]

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VIDEO: RHD genotyping for obstetric patients with a serologic weak D phenotype


Today we will be discussing patients that have a weak D phenotype for their Rh blood group antigen. Since the introduction of Rh immunoprophylaxis to prevent maternal-fetal alloimmunization, rates of severe and fatal hemolytic disease of the fetus and newborn have dramatically declined. Although laboratory practices in the United States are not consistent, blood donors […]

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VIDEO: Dabigatran Anticoagulation Reversal

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Today we will be discussing a new drug called idarucizumab, which was developed to reverse the anticoagulant effects of dabigatran. Dr. Charles who is leading a multi-center, prospective study of idarucizumab describes dabigatran: “Dabigatran is a direct oral anticoagulant that works by inhibiting the function of factor IIa, thrombin, and it’s been licensed for the […]

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VIDEO: Platelet Rich Plasma Standards Are Needed


Today we will be discussing platelet rich plasma or PRP. Autologous PRP injections are quite common and are used to aid in wound healing. Autologous PRP injections have become quite common in many clinical settings ranging from the orthopedic setting to dermatology, especially since major athletes such as Tiger Woods, Kobe Bryant and Hines Ward […]

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VIDEO: Transfusion-Transmitted Dengue Infections in Brazil

Dengue virus (DENV), artwork

Hello and welcome to Transfusion News. Today we will be discussing transfusion-transmitted dengue virus infections that occurred during the 2012 outbreak in Brazil. Dengue is now present in over 100 counties. Since 2002, there have been documented transfusion-transmitted infections in Hong Kong, Singapore, Puerto Rico, and Brazil. Dr. Brian Custer describes his study on transfusion-transmitted […]

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VIDEO: Implementation of Pathogen Reduction in the United States


Today we will be discussing pathogen reduction which inactivates bacteria, viruses and parasites that may contaminate blood products. European countries have been using pathogen reduction systems for over 10 years, and the FDA has recently approved pathogen reduction systems for platelets and plasma. Pathogen reduction technology for red cells is lagging, but is under development. […]

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