Alpha-Gal Syndrome as a Potential Cause of Allergic Transfusion Reactions Alpha-Gal syndrome (AGS) is an acquired allergic reaction caused by IgE antibodies against galactose-α-1-3-galactose (alpha-Gal), a carbohydrate expressed by most… September 9, 2026
α-Gal Sensitization in Group O Blood Recipients Linked to Severe Allergic Transfusion Reactions α-Gal sensitization was first described in 2009. It occurs when individuals develop IgE antibodies against the common mammalian disaccharide galactose-α-1,3-galactose… July 1, 2026
Mitochondrial DNA Acts as a “First Hit” for Antibody-Mediated TRALI Transfusion-related acute lung injury (TRALI) is the leading cause of transfusion-related mortality, but its pathogenesis is complex and not well… November 20, 2025
2024 Serious Hazards of Transfusions (SHOT) Report in the U.K. The Royal College of Pathologists in the United Kingdom recently published their annual report for 2024 on the Serious Hazards… August 6, 2025
Multi-Country Review of ABO-Incompatible Red Blood Cell Transfusions Safety measures to prevent ABO-incompatible red blood cell (RBC) transfusions are in place throughout the entire process from blood donation… November 26, 2024
Pathogenesis of Antibody-Mediated TRALI by Complement Transfusion-related acute lung injury (TRALI) is a rare, life-threatening adverse transfusion reaction that is difficult to predict and treat. The… January 25, 2024
Annual U.K. SHOT Report on Serious Hazards of Transfusions The Royal College of Pathologists in the United Kingdom recently published their annual report for 2022 on the Serious Hazards… July 26, 2023
Intracellular RBC Antigens Can Enhance RBC Alloimmunization in Mice RBC alloimmunization from transfusions or pregnancy can be life threatening. Currently, scientists have identified 43 polymorphic RBC surface antigen systems,… June 14, 2023
Risk Factors for Allergic Transfusion Reactions in Pediatric Patients Allergic transfusion reactions (ATRs) are common and can range from mild to severe. Younger age, hematological/oncological disease, increasing number of… May 17, 2022
X- and Gamma-Irradiation Impact Red Blood Cells Similarly Transfusion-associated graft versus host disease (TA-GVHD) is a rare complication that occurs when histoincompatible viable lymphocytes are transfused into an… November 22, 2021
Adverse Events (non-infectious)