Current RBC transfusion guidelines recommend a restrictive transfusion strategy for most patients, but ambiguity still remains for patients with high cardiac risk. The Transfusion Trigger after Operations in High Cardiac Risk Patients (TOP) trial compared restrictive (<7 g/dL) and liberal (<10 g/dL) transfusion strategies in adult veterans with high cardiac risk (e.g., heart or arterial disease, myocardial infarction, or stoke)…