CRISPR-Gene Editing Uses for Transfusion Medicine Clustered regularly interspaced short palindromic repeats (CRISPR) and Cas proteins evolved as part of the prokaryotes adaptive immune system. Cas… April 18, 2019
Novel Method to Expand Cord Blood Hematopoietic Stem Cells Hematopoietic stem cell (HSC) transplants can be life saving for many patients, including those with immune disorders, certain types of… August 15, 2018
Risk of Graft-Versus-Host Disease Dependent on Apheresis Device Used to Collect Allogeneic Stem Cells The composition of stem cell grafts can affect the risk of graft-versus-host disease (GvHD), time to engraftment, and relapse for… June 13, 2018
Gene Therapy for β-Thalassemia Patients who Are Transfusion Dependent β-thalassemia is one of the most common genetic diseases—especially in North Africa, the Middle East and Asia. About 60-80% of… April 25, 2018
Successful Treatment of Refractory B-cell Lymphomas with CAR T-Cell Therapy Chimeric antigen receptor (CAR) T-cell therapy has been shown to successfully treat refractory B-cell lymphomas. Two new studies published in… January 3, 2018
Gene Therapy for Hemophilia A Patients Successful Gene therapy using adeno-associated viral (AAV) vectors has been successfully used to treat patients with hemophilia B. Gene therapy for… December 28, 2017
Potential Screening for Cytomegalovirus among Cord Blood Donors Infection with cytomegalovirus (CMV) can cause severe complications for hematopoietic stem cell transplant patients. In addition to screening for maternal… November 9, 2017
FDA Approves CAR-T Gene Therapy for Acute Lymphoblastic Leukemia With the FDA approval of the first gene therapy, or a nucleic acid drug, we have entered a new era… September 7, 2017
Apheresis Lymphocyte Collections for CAR-T Cell Production Usually Well Tolerated By Cancer Patients Production of chimeric antigen receptor (CAR) T-cells involve genetically modifying the patient’s own T-cells, and these cells have been shown… May 17, 2017
Improving Peripheral Blood Stem Cell Collection for Autologous Stem Cell Transplantation The City of Hope National Medical Center in California performs nearly 400 autologous stem cell transplants (ASCT) per year using… January 11, 2017
Cell Therapy