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Cell Therapy

Novel Method to Expand Cord Blood Hematopoietic Stem Cells

Hematopoietic stem cell (HSC) transplants can be life saving for many patients, including those with immune disorders, certain types of…

August 15, 2018

Risk of Graft-Versus-Host Disease Dependent on Apheresis Device Used to Collect Allogeneic Stem Cells

The composition of stem cell grafts can affect the risk of graft-versus-host disease (GvHD), time to engraftment, and relapse for…

June 13, 2018

Gene Therapy for β-Thalassemia Patients who Are Transfusion Dependent

β-thalassemia is one of the most common genetic diseases—especially in North Africa, the Middle East and Asia.  About 60-80% of…

April 25, 2018

Successful Treatment of Refractory B-cell Lymphomas with CAR T-Cell Therapy

Chimeric antigen receptor (CAR) T-cell therapy has been shown to successfully treat refractory B-cell lymphomas. Two new studies published in…

January 3, 2018

Gene Therapy for Hemophilia A Patients Successful

Gene therapy using adeno-associated viral (AAV) vectors has been successfully used to treat patients with hemophilia B. Gene therapy for…

December 28, 2017

Potential Screening for Cytomegalovirus among Cord Blood Donors

Infection with cytomegalovirus (CMV) can cause severe complications for hematopoietic stem cell transplant patients. In addition to screening for maternal…

November 9, 2017

FDA Approves CAR-T Gene Therapy for Acute Lymphoblastic Leukemia

With the FDA approval of the first gene therapy, or a nucleic acid drug, we have entered a new era…

September 7, 2017

Apheresis Lymphocyte Collections for CAR-T Cell Production Usually Well Tolerated By Cancer Patients

Production of chimeric antigen receptor (CAR) T-cells involve genetically modifying the patient’s own T-cells, and these cells have been shown…

May 17, 2017

Improving Peripheral Blood Stem Cell Collection for Autologous Stem Cell Transplantation

The City of Hope National Medical Center in California performs nearly 400 autologous stem cell transplants (ASCT) per year using…

January 11, 2017

Mutating Haematopoietic Stem Cells May Cure Sickle Cell Disease

Sickle cell disease and β-thalassaemia are caused by mutations in the β -globin gene. Previous studies have shown that transplants…

November 16, 2016

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