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Special Transfusion Situations

Increased Blood Use and Cost for Emergency Transfusions with Whole Blood Compared to Packed Red Blood Cells

In the past two decades, a growing number of hospitals have started using whole blood to treat trauma patients and…

February 16, 2023

Whole Blood and Survival in Adult Trauma Patients

While blood component transfusions have been the standard of care for the past four decades, there is increasing interest in…

January 25, 2023

Plasmapheresis Associated with Reduced Mortality Among Patients with Severe COVID-19

Over 6 million people have died due to COVID-19 worldwide since the start of the pandemic.  Several comorbidities are associated…

January 18, 2023

Sickle Cell Trait Testing of RBC Units

While individuals with the sickle cell trait (SCT) have a single allele of hemoglobin S (HbS) and are eligible blood…

December 27, 2022

HbS Promotes Proinflammatory Cytokine Production in Sickle Cell Disease

Unlike patients with intravascular hemolysis without sickle cell disease (SCD) or those with β-thalassemia, patients with SCD have elevated baseline…

November 9, 2022

Transfusion Thresholds for Patients Receiving ECMO

Venovenous extracorporeal membrane oxygenation (ECMO) can be used to help provide respiratory support to patients with severe acute respiratory distress…

November 2, 2022

Results from Phase 1 Trial for Artificial Hemoglobin Vesicles

Advantages of artificial red blood cells (RBCs) include reduced risks of pathogens and alloimmunization and greater storage time compared to…

August 24, 2022

Hypocalcemia Associated with Increased Transfusion Requirements in Pediatric Trauma Patients

Hypocalcemia (Ca++ <1.1 mmol/L) has recently been identified as a fourth component of the “lethal triad” for mortality of adult…

July 27, 2022

Guidelines for Hemolytic Disease of the Newborn

Hemolytic disease of the newborn (HDN) is a serious disease associated with significant morbidity and mortality.   HDN occurs when maternal…

April 20, 2022

Drone Delivery of Blood Products Faster in Rwanda and Reduces Wastage

Over 75,000 units of blood components are transfused yearly in Rwanda, which is home to a population of approximately 13…

March 30, 2022

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