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Archives for May–August 2022

Mitapivat Trial Results in Adults with Pyruvate Kinase Deficiency Requiring Transfusions

Pyruvate kinase deficiency is a rare, congenital form of chronic hemolytic anemia.  Current treatments for pyruvate kinase deficiency, including RBC…

August 31, 2022

Results from Phase 1 Trial for Artificial Hemoglobin Vesicles

Advantages of artificial red blood cells (RBCs) include reduced risks of pathogens and alloimmunization and greater storage time compared to…

August 24, 2022

U.S. FDA Advises Blood Community Regarding Monkeypox Virus

The World Health Organization recently declared the current monkeypox epidemic a public health emergency.  First identified in laboratory monkeys in…

August 16, 2022

Safety and Effectiveness of Tranexamic Acid in Cardiac Surgery Patients

Tranexamic acid is an antifibrinolytic agent that is commonly used to control bleeding in patients undergoing cardiac surgery.  Limited randomized…

August 10, 2022

Racial Differences in Red Blood Cell Transfusions

Transfusion guidelines recommend transfusing red blood cells (RBCs) when hemoglobin (Hb) levels drop below 7 or 8 g/dL, but variation…

August 3, 2022

Hypocalcemia Associated with Increased Transfusion Requirements in Pediatric Trauma Patients

Hypocalcemia (Ca++ <1.1 mmol/L) has recently been identified as a fourth component of the “lethal triad” for mortality of adult…

July 27, 2022

New Alkaline Storage Solution Does Not Improve Post-Transfusion Recovery

During storage, red blood cells (RBCs) develop metabolic and morphological “storage lesions.”  The intracellular pH is an important variable that…

July 20, 2022

Prothrombin Complex Concentrate for Complex Cardiac Surgery Patients

Many cardiopulmonary bypass surgery patients with coagulopathy and bleeding require post-operative plasma transfusions.  Instead of plasma, the off-label use of…

July 14, 2022

Are WHO Guidelines for Serum Ferritin Levels for Female Blood Donors Too Low?

The current World Health Organization (WHO) guidelines, based on expert opinion with low-grade evidence, define iron deficiency in healthy blood…

July 6, 2022

Educational Materials Help to Retain Donors after a Temporary Deferral

Previous studies have found that temporarily deferred donors sometimes believe that their deferral is permanent.  In order to determine whether…

June 29, 2022

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