The United States reports the highest number of Babesia infections globally. Babesia, a tick-borne pathogen related to the malaria parasite, also infects RBCs leading to hemolytic anemia and other symptoms. Because blood donor testing is not universally implemented in the U.S. and individuals with sickle cell disease (SCD) require frequent transfusions, these individuals are vulnerable to transfusion-transmission of Babesia and…