Red blood cells (RBCs) deliver oxygen to tissues and also contribute to hemostasis and thrombosis through platelet interactions that promote clot formation. In addition, RBC release adenosine 5′-diphosphate (ADP) and extracellular vesicles, which promote procoagulant conditions. It has also been observed that prolonged bleeding times can be reduced in anemic patients with RBC transfusions, but the physiology was unknown. To…
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