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New Human Virus Discovered in Transfusion Recipients

October 9, 2015

Conceptual image of hepatitis virus.

Researchers identified a new human virus in serum samples from transfusion recipients. The new virus is related to hepatitis C virus and the human pegaivrus (HPgV, also known as hepatitis G virus).

By using a sequence-independent approach to examine both known and unknown viruses at pre- and post-transfusion, samples from 44 individuals enrolled in the Transfusion-Transmitted Viruses Study from 1974-1980 were compared for changes in viromes pre- and post-transfusion.  Two transfusion recipients harbored a new virus called human hepegivirus 1 (HHpgV-1).  The new virus was also identified in two hemophilia patients enrolled in the Multicenter Hemophilia Cohort Study, which was conducted between 1982-1986.  After sequencing the 9,538-nucleotide genome of HHpgV-1, researchers found that the 5’ untranslated region was similar to pathogenic HCV, and the non-structural genes had similar homology to non-pathogenic HPgV.  Further studies are needed to develop a serologic assay for this virus, confirm the prevalence of HHpgV-1 in transfused blood, and determine whether there are any clinical implications of being infected by this virus.

Reference

  1. Kapoor A, Kumar A, Simmonds P, Bhuva N, Chauhan LS, Lee B, Sall AA, Jin Z, Morse SS, Shaz B, Burbelo PD, Lipkin WI. Virome analysis of transfusion recipients reveals a novel human virus that shares genomic features with hepaciviruses and pegiviruses.  Mbio 2015; 6(5): e01466-15.

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