Inventory and storage of cryopreserved platelets (CPP) would be simple in comparison to platelets that are normally stored at room temperature for up to 7 days. Previous in vivo studies have suggested that CPPs are safe and hemostatically effective. However, in vitro studies have provided discrepant results. In order to investigate the in vitro properties of CPP, fresh whole blood was collected from 8 donors. In this 4-arm study, hemostatic properties of whole blood were compared to platelet-depleted whole blood, and whole blood with restored platelets (cryopreserved or stored in standard liquid for 5 days). Results suggest that CPP-restored whole blood has the fastest clotting time, can form stable platelet clots, and can effectively support the conversion of prothrombin to thrombin and fibrin without a risk of thrombosis. Further research into the safety of CPP in vivo is necessary as CPPs may be helpful in some clinical settings.
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