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T cell Mediated Platelet Refractoriness

April 13, 2016

Blood cells, SEM

Patients who are refractory to platelet transfusion are a challenge for transfusion services. Platelet refractoriness has historically been attributed to antibodies to platelet MHC, ABO blood group antigen and human platelet antigen 1.  However, other potential causes of platelet refractoriness may exist.

In a recent study published in Blood, researchers compared platelet refractoriness in healthy mice to mice with a B-cell deficiency that inhibited antibody production, and they found that both types of mice were able to similarly clear mismatched transfused platelets.  Immune-mediated clearance of platelets occurred in the absence of anti-MHC antibodies.  Results of the study revealed that CD8+ T cells were important in platelet clearance.  Additional studies of this newly recognized mechanism of platelet clearance may lead to novel methods to assist patients who are refractory to platelet transfusion.

 

 

References

  1. Arthur CM, Patel SR, Sullivan HC, Winkler AM, Tormey CA, Hendrickson JE, Stowell SR. CD8+ T cells mediate antibody-independent platelet clearance in mice. Blood 2016;127: 1823-7.
  2. Manis JP, Silberstein LE. Platelet refractoriness: it’s not the B-all and end-all. Blood 2016;127: 1740-1.

Filed Under

  • News
  • Platelet Transfusion

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