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Characteristics of Transfusion Recipients in the United States

November 29, 2017

The Recipient Epidemiology and Donor Evaluation Study-III (REDS-III) has gathered detailed information on both inpatient and outpatient transfusions over the past 6 years in the United States. Data from a two year period (2013-14) collected from 12 U.S. hospitals in four regions among inpatients was recently published in Transfusion.  Based on 641,751 inpatients, 12.5% (80,362) received a transfusion—the majority were transfused with RBCs (10.9%).  Platelet and plasma transfusions occurred less frequently (3.2% and 2.9%, respectively).  Almost one half (47%) of all transfused units were issued in the general wards; 25.7% of units were used in the ICU and 19.8% in the operating room.  The mean hemoglobin level for transfused patients was 7.6 g/dL, which is consistent with restrictive transfusion approaches.  Patient mortality with regard to transfusions increased with age, number of units transfused, and the use of platelets or plasma.  Febrile non-hemolytic reactions were the most commonly reported adverse events.  Large, comprehensive databases such as the REDS-III are a valuable resource that researchers can utilize to help make transfusions safer for patients.

Reference:

  1. Karafin MS, Bruhn R, Westlake M, et al. Demographic and epidemiologic characterization of transfusion from four US regions: evidence from the REDS-III recipient database. Transfusion 2017; online doi:10.1111/trf.14370

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