Distinct Roles for Differently Aged Platelets Platelets are derived from megakaryocytes in the bone marrow and have a lifespan of about seven to ten days in… April 23, 2025
Prothrombin Complex Concentrate Is Safe and Effective for Cardiac Surgery Patients with Coagulopathic Bleeding Around 15% of cardiac surgery patients experience excessive bleeding, often due to a depletion of coagulation factors. Up to 30%… April 2, 2025
Plasma Transfusion Practices in ICUs Globally Platelet transfusion guidelines discourage prophylactic plasma transfusion for non-bleeding patients, yet findings from the International Point Prevalence Study of Intensive… February 18, 2025
RBCs Regulate Hemostasis Through Platelet-Dependent and -Independent Mechanisms Red blood cells (RBCs) deliver oxygen to tissues and also contribute to hemostasis and thrombosis through platelet interactions that promote… October 9, 2024
Recombinant ADAMTS13 Treatment for Congenital Thrombotic Thrombocytopenic Purpura Congenital thrombotic thrombocytopenic purpura (TTP) is a rare disease caused by a severe hereditary deficiency of ADAMTS13, which normally cleaves… May 15, 2024
Increasing Data Available for Plasma Transfusion Indications Plasma transfusions are often used to prevent and/or treat bleeding and to control blood volume in patients with trauma or… April 23, 2024
Safety of Platelet and Plasma Transfusions in the COVID-19 Era By September 2022, 96% of U.S. blood donors had antibodies to SARS-CoV-2 due to infection and/or vaccination. Some patient advocacy… December 13, 2023
COVID-19 Convalescent Plasma Reduces Mortality for Patients with Acute Respiratory Distress Syndrome COVID-19 mortality among patients in the intensive care unit receiving mechanical ventilation is around 45%, and little data exists on… November 8, 2023
Recombinant von Willebrand Factor and Tranexamic Acid for Menstruating Women with von Willebrand Disease Von Willebrand disease is an inherited bleeding disorder affecting about 0.1% of the population. Von Willebrand disease is caused by… September 13, 2023
Concizumab Lowers Rate of Bleeding in Hemophilia Patients with Inhibitors While current guidelines for treating patients with hemophilia A or B recommend intravenous factor VIII or IX concentrates, many patients… September 6, 2023
Coagulation & Plasma Transfusion