HbS Promotes Proinflammatory Cytokine Production in Sickle Cell Disease Unlike patients with intravascular hemolysis without sickle cell disease (SCD) or those with β-thalassemia, patients with SCD have elevated baseline… November 9, 2022
Transfusion Thresholds for Patients Receiving ECMO Venovenous extracorporeal membrane oxygenation (ECMO) can be used to help provide respiratory support to patients with severe acute respiratory distress… November 2, 2022
ABO and Lewis Blood Groups Linked to Lower COVID-19 Susceptibility Blood group O has been associated with decreased risk of SARS-CoV-2 infection in several small studies. In order to confirm… October 26, 2022
Pluripotent Stem Cell Gene Editing Provides Rare RBC Screening Cells Over 10 million of RBC units are transfused each year in the U.S. alone. Alloimmunization and hemolytic transfusion reactions pose… October 19, 2022
Individualized Behavior-Based MSM Donor Eligibility Would Increase Pool of Potential Donors In order to reduce the risk of blood transfusion-associated HIV transmission during the window period between exposure and detectability among… October 12, 2022
Sex-Matched Transfusions May Reduce Mortality While plasma from female donors increases the risk of transfusion-related acute lung injury (TRALI), observational studies have had conflicting results… October 6, 2022
Iron Repletion Does Not Effect Donor Well-Being or Red Cell Quality Iron deficiency develops in over one third of regular, repeat blood donors. In order to exam the physiological consequences of… September 28, 2022
Prophylactic Tranexamic Acid Does Not Decrease Bleeding or Transfusions in Patients with Hematologic Malignancies Patients with hematologic malignancies account for 43% of the 2 million platelet doses transfused in the U.S. each year. Despite… September 21, 2022
Donor Deferral Recommendations for HIV Pre-exposure Prophylaxis In December 2021, the U.S. FDA approved injectable cabotegravir (Apretude) as pre-exposure prophylaxis (PrEP) to prevent HIV transmission. PrEP, post-exposure… September 14, 2022
SARS-CoV-2 RNA Frequently Found in Blood Donor Plasma is Not Infectious Although no cases of SARS-CoV-2 transfusion-transmission have been reported worldwide, RNA is detected in 15% to 90% of patients with… September 7, 2022
