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Archive by Topic » News

Updated Guidance for COVID-19 Convalescent Plasma Use from the FDA and AABB

With a lack of effective treatments for COVID-19, the U.S. FDA issued Emergency Use Authorization to use convalescent plasma to…

February 17, 2021

Platelet Extracellular Vesicles Formed During Storage May Be Causative Agents in Non-Antibody-Mediated TRALI

Transfusion-related acute lung-injury (TRALI) is a rare but potentially fatal complication of plasma transfusions affecting 1 in 10,000 transfusions and…

February 9, 2021

Antigen Density on Surface of RBCs a Factor in RBC Clearance in Incompatible Transfusions

Select patients with chronic anemia and sickle cell disease require recurrent transfusions and are at risk for alloimmunization and potentially…

February 3, 2021

Epitope Matched HLA Platelets Are Noninferior to Standard Matched HLA Platelets

Alloimmunization to human leukocyte antigens (HLA) leads to platelet refractoriness, defined as decreased post-transfusion platelet count increments (PCIs), and is…

January 27, 2021

RHD Genotyping in Transfusion Practice Could Identify Novel RHD Alleles and Conserve D-negative Blood

Partial D phenotypes (with altered D epitopes) and weak D phenotypes (with a reduced number of D antigens present on…

January 20, 2021

Early Convalescent Plasma Therapy Helps Prevent Severe COVID-19

COVID-19 convalescent plasma administered late in the course of disease has not shown clear benefits, but some studies suggest that…

January 12, 2021

Higher Hemoglobin Transfusion Thresholds Do Not Improve Outcomes in Preterm Infants

Within the last decade, lower hemoglobin transfusion thresholds have been found to be safe and effective for most patient subpopulations. …

January 5, 2021

Serological Screening of Blood Donations Suggests SARS-CoV-2 May Have Been Introduced in the US before January 2020

The first case of SARS-Cov-2 in the United States was reported on January 19, 2020 in Washington State, but phylogenic…

December 22, 2020

CRISPR-Cas9 Gene Editing and Lentiviral Gene Therapy Hold Promise to Treat Transfusion Dependent β-Globin Hemoglobinopathies

Both transfusion-dependent β-thalassemia (TDT) and sickle cell disease (SCD) are common monogenetic diseases caused by mutations in the gene encoding…

December 15, 2020

NT-proBNP Levels May Help Diagnose TACO and TRALI

Distinguishing between transfusion-associated circulatory overload (TACO), transfusion-related acute lung injury (TRALI), and other pulmonary transfusion reactions, including transfused-associated acute respiratory…

December 9, 2020

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