Eculizumab for Treating Cold Agglutinin Disease Cold agglutinin disease (CAD) is a rare autoimmune disease caused by antibodies directed against red blood cell antigens, making them… October 24, 2018
Increased Risk of Myocardial Ischemia and Death in Severely Anemic Patients who Decline Transfusions Increased cardiac output can aid oxygen delivery in patients with mild anemia. When a critical hemoglobin (Hb) concentration is reached… October 10, 2018
Blood Collection and Processing Methods Affect Inflammatory Response in Vitro Numerous studies have examined whether storage time affects the safety and quality of red blood cells (RBCs), but few studies… October 3, 2018
Matching RH Genotypes for Patients with Sickle Cell Disease RH antigens are encoded by two highly polymorphic genes, RHD and RHCE. Homologous recombination and novel polymorphism have resulted in… September 19, 2018
Restrictive Transfusion Strategy for Cardiac Surgery Patients Previous studies have reported that restrictive transfusion strategies are non-inferior compared to liberal strategies for cardiac surgery patients followed up… August 30, 2018
Presence of Cell-free Nucleic Acids in Blood Products Cell-free nucleic acids (CFNAs) are often present in plasma. A new study tested whether CFNAs are also present and active… July 25, 2018
Behavior Modifications Support Changes to Restrictive RBC Transfusion Practices Accumulating evidence supports restrictive RBC transfusion practices, and guidelines such as those recently released by the AABB recommend transfusing when… June 27, 2018
Perioperative RBC Transfusions Linked to Increased Risk of Blood Clots Venous thromboembolism (VTE) is associated with 5-10% of all hospital deaths, or about 100,000 to 200,000 deaths each year in… June 20, 2018
Transfusion Dependence for Leukemia Patients Shortens Hospice Stay Approximately 25,000 individuals in the United States die annually from leukemia. These individuals often require transfusions; however, hematologic oncologists have… June 6, 2018
Universal Donor Red Blood Cells Can Be Genetically Engineered Using CRISPR Gene Editing Alloimmunization commonly affects 2-5% of all transfusion recipients and approximately 30% of chronically transfused patients with sickle-cell disease. Since ABO… May 2, 2018
RBC Transfusion