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Serology/Genotyping

RBCeq: A Novel, User-Friendly, Algorithm for Genetic Blood Typing

About 85 million units of red blood cells (RBCs) are transfused globally, and some patients requiring multiple transfusions are at…

January 26, 2022

Epitope Matched HLA Platelets Are Noninferior to Standard Matched HLA Platelets

Alloimmunization to human leukocyte antigens (HLA) leads to platelet refractoriness, defined as decreased post-transfusion platelet count increments (PCIs), and is…

January 27, 2021

RHD Genotyping in Transfusion Practice Could Identify Novel RHD Alleles and Conserve D-negative Blood

Partial D phenotypes (with altered D epitopes) and weak D phenotypes (with a reduced number of D antigens present on…

January 20, 2021

High Seroprevalence of SARS-CoV-2 in Kenyan Blood Donors

As of late July 2020, only 3% of recorded deaths due to COVID-19 have occurred in Africa despite being home…

November 25, 2020

High-throughput Blood Antigen Array Genotyping for Blood Donors

Alloimmunization to red blood cell (RBC), human leukocyte (HLA), and human platelet (HPA) antigens can lead to hemolytic transfusion reactions…

September 1, 2020

Enzymatic Conversion of Group A Blood to Universal Group O Blood

As reported in Nature Microbiology, researchers have identified a set of enzymes isolated from human gut bacteria that convert the…

June 26, 2019

Anti-CD47 Interference with Serological Testing

Immunotherapy, the use of humanized monoclonal antibodies, is a promising therapy that works in conjunction with the patient’s own immune…

February 6, 2019

Matching RH Genotypes for Patients with Sickle Cell Disease

RH antigens are encoded by two highly polymorphic genes, RHD and RHCE.  Homologous recombination and novel polymorphism have resulted in…

September 19, 2018

Typing Blood Group Variants from Whole-Genome Sequencing Data

Serological testing for ABO and RhD blood group compatibility has been standard practice for at least 60 years. ABO and…

May 30, 2018

High-Throughput Exome Sequencing Clarifies Serology Typing and Helps Identify Rare and Novel Blood Group Alleles

 Next Generation Sequencing (NGS), also known as high-throughput sequencing and massively parallel sequencing, is a revolutionary sequencing technique that amplifies…

February 7, 2018

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