High Seroprevalence of SARS-CoV-2 in Kenyan Blood Donors As of late July 2020, only 3% of recorded deaths due to COVID-19 have occurred in Africa despite being home… November 25, 2020
High-throughput Blood Antigen Array Genotyping for Blood Donors Alloimmunization to red blood cell (RBC), human leukocyte (HLA), and human platelet (HPA) antigens can lead to hemolytic transfusion reactions… September 1, 2020
Enzymatic Conversion of Group A Blood to Universal Group O Blood As reported in Nature Microbiology, researchers have identified a set of enzymes isolated from human gut bacteria that convert the… June 26, 2019
Anti-CD47 Interference with Serological Testing Immunotherapy, the use of humanized monoclonal antibodies, is a promising therapy that works in conjunction with the patient’s own immune… February 6, 2019
Matching RH Genotypes for Patients with Sickle Cell Disease RH antigens are encoded by two highly polymorphic genes, RHD and RHCE. Homologous recombination and novel polymorphism have resulted in… September 19, 2018
Typing Blood Group Variants from Whole-Genome Sequencing Data Serological testing for ABO and RhD blood group compatibility has been standard practice for at least 60 years. ABO and… May 30, 2018
High-Throughput Exome Sequencing Clarifies Serology Typing and Helps Identify Rare and Novel Blood Group Alleles Next Generation Sequencing (NGS), also known as high-throughput sequencing and massively parallel sequencing, is a revolutionary sequencing technique that amplifies… February 7, 2018
Transfusion Testing Strategies for Multiple Myeloma Patients Undergoing Anti-CD38 Therapy Anti-CD38 therapies such as daratumumab have increased survival time for patients with multiple myeloma. This novel therapy, however, interferes with… February 10, 2017
KEL-Antigen Modulation is Important for Anti-KEL Immunoprophylaxis Rh immunoglobulin therapy has been used for more than 60 years to prevent alloimmunization in Rh-negative pregnant women carrying an… January 5, 2017
Dithiothreitol (DTT)-based Method Validated for Blood Compatibility Testing in Patients Taking Daratumumab Daratumumab (DARA), an immunoglobulin that targets CD38 on myeloma cells, was recently approved by the U.S. FDA. DARA, however, also… September 14, 2016
Serology/Genotyping