• Skip to main content
  • Skip to primary sidebar
Transfusion News
  • About Us
  • Topics
    • Adverse Events (non-infectious)
    • Blood Donation
    • Cell Therapy
    • Coagulation & Plasma Transfusion
    • Platelet Transfusion
    • Policy and Guidelines
    • Quality Control and Regulatory
    • RBC Transfusion
    • Serology/Genotyping
    • Special Transfusion Situations
    • Transfusion Transmitted Infections
  • Continuing Education
  • Archives
  • Podcasts
  • Question of the Day
  • Search
  • Subscribe to Email Alerts
  • Follow us on
  • Search
  • Subscribe to Email Alerts

Eculizumab for Treating Cold Agglutinin Disease

October 24, 2018

Cold agglutinin disease (CAD) is a rare autoimmune disease caused by antibodies directed against red blood cell antigens, making them agglutinate at colder temperatures and activate complement. Current treatments for CAD are limited and include avoiding cold temperatures, inhibiting B-cell production of autoantibodies, and providing transfusions to combat hemolysis.  Researchers in Germany recently conducted a non-randomized, phase 2 clinical trial in 13 patients with CAD to test the safety and efficacy of eculizumab—a monoclonal antibody which inhibits complement by binding complement factor C5.  Patients received eculizumab weekly for 4 weeks and then biweekly through 26 weeks.  While eculizumab did not reduce cold-induced circulatory symptoms, the median lactate dehydrogenase level (indicative of hemolysis) decreased from 572 U/L to 334 U/L (p=0.02) and hemoglobin levels increased from 9.35 g/dL to 10.15 g/dL (p=0.04).  Furthermore, the number of RBC units transfused was less than projected—8 patients did not need any transfusions and one additional patient received fewer transfusions than expected.  Adverse events (mainly mild or moderate) were reported in 5 patients. Additional studies examining the efficacy of eculizumab for CAD treatment are needed.

Reference:

  1. Röth A, Bommer M, Hüttman A, Herich-Terhüme D, Kuklik N, Rekowski J, Lenz V, Schrezenmeier H, and Dührsen U.   Eculizumab in cold agglutinin disease (DECADE): an open-label, prospective, bicentric, nonrandomized phase 2 trial. Blood Advances 2018; 2(19); 2543-2579.   

Filed Under

  • News
  • RBC Transfusion
  • Special Transfusion Situations

Recommended

  • Delayed Hemolytic Transfusion Reactions are Under Diagnosed in Patients with Sickle Cell Disease

  • COVID-19 Convalescent Plasma Provides More than Neutralizing Antibodies

  • SARS-CoV-2 RNA Frequently Found in Blood Donor Plasma is Not Infectious

Show Comments

Comments on this article are closed.

Get the latest news. Subscribe to our mailing list. Sign Up

Primary Sidebar

Latest News

  • Directed Blood Donations Should be Limited

  • Babesia Infection Reduces Red Cell Deformability

  • New Erythropoietin Gene Variants Linked to Hereditary Erythrocytosis

  • Multifaceted Threats to the Blood Supply from Climate Change

    Question of the Day

    Copyright © 2025 John Wiley & Sons, Inc. All Rights Reserved.
    Privacy Policy

    Association for the Advancement of Blood and Biotherapies Wiley