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Adverse Events (non-infectious)

Multi-Country Review of ABO-Incompatible Red Blood Cell Transfusions

Safety measures to prevent ABO-incompatible red blood cell (RBC) transfusions are in place throughout the entire process from blood donation…

November 26, 2024

Pathogenesis of Antibody-Mediated TRALI by Complement

Transfusion-related acute lung injury (TRALI) is a rare, life-threatening adverse transfusion reaction that is difficult to predict and treat. The…

January 25, 2024

Annual U.K. SHOT Report on Serious Hazards of Transfusions

The Royal College of Pathologists in the United Kingdom recently published their annual report for 2022 on the Serious Hazards…

July 26, 2023

Intracellular RBC Antigens Can Enhance RBC Alloimmunization in Mice

RBC alloimmunization from transfusions or pregnancy can be life threatening.  Currently, scientists have identified 43 polymorphic RBC surface antigen systems,…

June 14, 2023

Risk Factors for Allergic Transfusion Reactions in Pediatric Patients

Allergic transfusion reactions (ATRs) are common and can range from mild to severe.  Younger age, hematological/oncological disease, increasing number of…

May 17, 2022

X- and Gamma-Irradiation Impact Red Blood Cells Similarly

Transfusion-associated graft versus host disease (TA-GVHD) is a rare complication that occurs when histoincompatible viable lymphocytes are transfused into an…

November 22, 2021

T helper Cells and Alloimmunization in Patients with Sickle Cell Disease

Alloimmunization can lead to life-threatening hemolytic transfusion reactions and make it difficult to  find compatible blood.  While it is unknown…

March 16, 2021

Antigen Density on Surface of RBCs a Factor in RBC Clearance in Incompatible Transfusions

Select patients with chronic anemia and sickle cell disease require recurrent transfusions and are at risk for alloimmunization and potentially…

February 3, 2021

NT-proBNP Levels May Help Diagnose TACO and TRALI

Distinguishing between transfusion-associated circulatory overload (TACO), transfusion-related acute lung injury (TRALI), and other pulmonary transfusion reactions, including transfused-associated acute respiratory…

December 9, 2020

Convalescent Plasma for COVID-19 Safe in First 5,000 Patients

With limited therapies for patients with COVID-19 and a mortality rate of approximately 50% for patients in the ICU, demand…

May 19, 2020

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