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Archives for September–December 2022

Sickle Cell Trait Testing of RBC Units

While individuals with the sickle cell trait (SCT) have a single allele of hemoglobin S (HbS) and are eligible blood…

December 27, 2022

Prothrombin Complex Concentrate Reduces RBC Transfusions during Cardiac Surgery

Over one million people undergo complex cardiac surgeries worldwide each year.  Cardiac surgeries carry a considerable risk of postoperative bleeding…

December 21, 2022

Updated FDA Guidance to Reduce the Risk of Transfusion-Transmitted Malaria

In April 2020, the U.S. Food and Drug Administration (FDA) issued four blood donor eligibility guidelines—including one for malaria—to help…

December 13, 2022

First Autologous Human Transfusion of Engineered Platelets

Approximately 2 million units of platelets are transfused each year in the United States, but there are many drawbacks and…

December 7, 2022

Clinical Predictors of Fetal and Neonatal Alloimmune Thrombocytopenia (FNAIT)

Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is a rare, life-threatening condition in pregnancy and is the leading cause of intracranial…

November 30, 2022

Hypoxic Storage Helps to Preserve Red Blood Cells

Red blood cells (RBCs) may be stored for up to 42 days, but over time storage lesions also develop.  These…

November 22, 2022

High-Titer Convalescent Plasma Increases Long-Term Survival for Patients with Severe COVID-19

Randomized controlled clinical trials have evaluated the safety and efficacy of COVID-19 convalescent plasma (CCP) and found high-titer CCP reduced…

November 16, 2022

HbS Promotes Proinflammatory Cytokine Production in Sickle Cell Disease

Unlike patients with intravascular hemolysis without sickle cell disease (SCD) or those with β-thalassemia, patients with SCD have elevated baseline…

November 9, 2022

Transfusion Thresholds for Patients Receiving ECMO

Venovenous extracorporeal membrane oxygenation (ECMO) can be used to help provide respiratory support to patients with severe acute respiratory distress…

November 2, 2022

ABO and Lewis Blood Groups Linked to Lower COVID-19 Susceptibility

Blood group O has been associated with decreased risk of SARS-CoV-2 infection in several small studies.  In order to confirm…

October 26, 2022

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