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Search Results for: Sickle cell

Sickle Cell Trait Testing of RBC Units

While individuals with the sickle cell trait (SCT) have a single allele of hemoglobin S (HbS) and are eligible blood…

December 27, 2022

HbS Promotes Proinflammatory Cytokine Production in Sickle Cell Disease

Unlike patients with intravascular hemolysis without sickle cell disease (SCD) or those with β-thalassemia, patients with SCD have elevated baseline…

November 9, 2022

LentiGlobin Therapy for Sickle Cell Disease

Sickle cell disease (SCD) is caused by a single point mutation in the β-globin gene and affects around 100,000 people…

January 4, 2022

Cost-Effectiveness of Transfusions to Prevent Silent Cerebral Infarcts in Children with Sickle Cell Disease

Guidelines published by the American Society of Hematology in 2020 recommend annual transcranial doppler ultrasound (TCD) screening to help identify…

December 29, 2021

Reducing Red Cell Use for Patients with Sickle Cell Disease during a Pandemic

Since March 2020, the COVID-19 pandemic has strained blood inventories, so researchers at one Philadelphia hospital implemented new measures to…

June 30, 2021

T helper Cells and Alloimmunization in Patients with Sickle Cell Disease

Alloimmunization can lead to life-threatening hemolytic transfusion reactions and make it difficult to  find compatible blood.  While it is unknown…

March 16, 2021

Experimental Drug Voxelotor for Treatment of Patients with Sickle Cell Disease

Results from a multicenter, randomized, clinical trial suggests that voxelotor, which inhibits sickle hemoglobin (HbS) polymerization, may be beneficial for…

July 3, 2019

Delayed Hemolytic Transfusion Reactions are Under Diagnosed in Patients with Sickle Cell Disease

Red blood cell transfusions are often used to treat patients with sickle cell disease (SCD), and these patients are at…

May 1, 2019

Matching RH Genotypes for Patients with Sickle Cell Disease

RH antigens are encoded by two highly polymorphic genes, RHD and RHCE.  Homologous recombination and novel polymorphism have resulted in…

September 19, 2018

Red Cell Exchange for Patients with Sickle Cell Disease: an AABB Report

The Therapeutic Apheresis Subsection of the AABB, composed of 15 practicing apheresis physicians from 14 institutions, recently summarized how they…

September 12, 2018

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