Liberal Transfusion Thresholds for Patients with Acute Brain Injury Over the past 25 years, >45 randomized clinical trials have shown that a restrictive transfusion strategy is best for most… October 17, 2024
RBCs Regulate Hemostasis Through Platelet-Dependent and -Independent Mechanisms Red blood cells (RBCs) deliver oxygen to tissues and also contribute to hemostasis and thrombosis through platelet interactions that promote… October 9, 2024
Liberal Transfusion Threshold of 9-10 g/dL for Patients with Myocardial Infarction While restrictive transfusion hemoglobin (Hb) thresholds are appropriate for most patients, those with anemia and myocardial infarction (MI) may benefit… October 2, 2024
Prevalence and Trends of Maternal RBC Alloimmunization in the U.S. Maternal alloimmunization to RBC antigens, whether from blood transfusion or exposure to fetal antigens during pregnancy, can lead to hemolytic… September 4, 2024
Tranexamic Acid Does Not Reduce Bleeding or Transfusions in Patients Undergoing Liver Resection Tranexamic acid is a synthetic compound that prevents fibrin clot degradation and has been shown to reduce blood loss and… August 27, 2024
Nipocalimab Delays Intrauterine Transfusions for Severe Hemolytic Disease of the Fetus and Newborn Severe hemolytic disease of the fetus and newborn (HDFN) results from red blood cell (RBC) antigen incompatibility when IgG molecules… August 14, 2024
Monitoring Oxygen Saturation and Hemoglobin Values along with Iron and Erythropoietin Supplementation Reduces RBC Transfusion Frequency Approximately 20-40% of cardiac surgery patients have pre-operative anemia, and about half are transfused. Randomized controlled trials have shown intravenous… August 7, 2024
Carnitine Metabolism Associated with Red Blood Cell Hemolysis Red blood cells can be stored up to 42 days, after which they progressively develop a series of storage lesions—partly… July 25, 2024
RBC Transfusions Guidelines for Very Preterm Infants Most clinical practice guidelines for blood transfusion have focused on adults and limited recommendations are available for children and neonates…. July 9, 2024
Liberal versus Restrictive Transfusion Strategy for Patients with Traumatic Brain Injury and Anemia While a restrictive RBC transfusion strategy has been shown to be safe and effective for most patients, there is uncertainty… June 19, 2024
RBC Transfusion