Mitochondrial DNA Acts as a “First Hit” for Antibody-Mediated TRALI Transfusion-related acute lung injury (TRALI) is the leading cause of transfusion-related mortality, but its pathogenesis is complex and not well… November 20, 2025
Liberal or Restrictive Transfusion Thresholds for Surgery Patients with High Cardiac Risk Current RBC transfusion guidelines recommend a restrictive transfusion strategy for most patients, but ambiguity still remains for patients with high… November 12, 2025
Iron Supplementation for Blood Donors Based on Ferritin Levels With each whole blood donation, donors lose approximately 250 mg of iron and have a higher risk of developing iron… November 5, 2025
Impact of Individual Donor Assessment Deferral Changes on Donor HIV, HBV, HCV, and Syphilis Prevalence In 2023, the U.S. Food and Drug Administration (FDA) guidelines for blood donations shifted from a 3-month deferral for donors… October 29, 2025
RBC Transfusions in Neonatal ICUs Above Restrictive Hb Thresholds In 2020, two randomized clinical trials found that liberal RBC transfusion hemoglobin (Hb) thresholds were non-superior to restrictive thresholds for… October 23, 2025
Locally Transmitted Malaria in the United States Currently, half of the world’s population is at risk for malaria. Although malaria was endemic across the southern region of… October 15, 2025
Global Platelet Transfusion Practices for Patients in the ICU Platelet transfusion rates for patients in the ICU range from 5% to 15%, but guidelines are primarily based on observational… October 8, 2025
Plasma Equivalent to Clotting Factor Concentrates for Initial Resuscitation of Patients with Severe Trauma The incidence of trauma-induced coagulopathy (TIC) is related to the severity of injury and occurs in about 25% of trauma… October 2, 2025
Personalized Prediction Model of Prophylactic Platelet Transfusions for Preterm Infants International transfusion guidelines based on one large randomized controlled trial for preterm infants with severe thrombocytopenia (platelet count < 50… September 24, 2025
Caffeine in Donor Blood Reduces Quality of Stored RBCs Caffeine, one of the most consumed psychoactive substances worldwide, is a non-selective antagonist of adenosine receptors, including ADORA2B expressed on… September 16, 2025
