Female Sex is not an Independent Risk Factor for Red Blood Cell Alloimmunization Researchers from the Sanquin-LUMC in the Netherlands have concluded that female sex alone is not sufficient to recommend extended crossmatching… October 5, 2012
Phosphatidylserine and Phosphatidylethanolamine Levels on RBCs Important for Transfusion Outcomes Phosphatidylserine (PS) and phosphatidylethanolamine (PE) are phospholipids that normally reside in the inner leaflet of the red blood cell membrane…. December 10, 2025
RHD Genotyping May Enable D-positive RBC Units to be Transfused to Patients with Anti-D Patients with sickle cell disease (SCD) often require chronic red blood cell exchanges. The American Society for Hematology recommends matching… November 13, 2024
Intravenous vs Oral Iron for Pregnant Women in Africa Worldwide, almost 40% of all pregnant women are anemic (hemoglobin < 11 g/dL) with the percentage rising to around 50%… November 7, 2024
Global Blood Supply Challenges The World Health Organization (WHO) considers blood an essential medicine, yet nearly two-thirds of countries—primarily low- and middle-income countries (LMIC)—lack… September 11, 2024
Motivators and Barriers to Donating Blood Among African Americans In the U.S., blood donations rates are lower among African Americans than the general population. The National Heart, Lung, and… April 3, 2024
Platelet-RBC Complexes Associated with RBC Clearance Platelet-RBC (P-RBC) complexes are associated with several diseases such as sickle cell disease, malaria, and immune thrombocytopenia. Since diseased RBCs… February 21, 2024
Low Alloimmunization Risk if No Antibodies Formed during First 20 RBC Transfused Units RBC transfusions are critical for many patients with sickle cell disease. Patients are at risk, however, of developing alloantibodies, which… January 4, 2024
Antigen Density on Surface of RBCs a Factor in RBC Clearance in Incompatible Transfusions Select patients with chronic anemia and sickle cell disease require recurrent transfusions and are at risk for alloimmunization and potentially… February 3, 2021
CRISPR-Cas9 Gene Editing and Lentiviral Gene Therapy Hold Promise to Treat Transfusion Dependent β-Globin Hemoglobinopathies Both transfusion-dependent β-thalassemia (TDT) and sickle cell disease (SCD) are common monogenetic diseases caused by mutations in the gene encoding… December 15, 2020
